Guidelines and instructions for 2-year grant applications


GUIDELINES AND INSTRUCTIONS FOR 2-YEAR GRANT APPLICATIONS

 

BACKGROUND

 

 

The Alzheimer Research Foundation (SAO-FRA) awards grant applications in the areas of Basic and Clinical research of Alzheimer disease and related disorders. Grant applications are accepted from principle investigators with a PhD degree and working at Belgian non-profit research organizations.

 

Alzheimer disease Grant Application categories:

 

Standard Grant Applications: research proposals have to be written for a 2-years award period. The amount of this award is fixed at € 150.000. Only scientists, with a minimum of three years post PhD graduation date at the start of the Award period, are eligible applicants in this award category. Applicants should be experienced in research into Alzheimer disease and related disorders.

 

Pilot Grant Applications: research proposals have to be written for a 2-years award period. *

The amount of this award is fixed at 75.000. Only young scientists, with a maximum of three years post PhD graduation date at the start of the Award period, are eligible applicants in this award category. Young researchers have to be legally associated with an experienced research team working on Alzheimer disease and related disorders.

(*) For those projects which can be finished in a one-year period, the applicants must mention this in their application. The scientific advisory board of SAO-FRA will examine this request and make a decision.

Extra funding: Every year one Standard Grant will be selected & funded by the “Fund Aline”, managed by the King Baudouin Foundation through a fund of € 100.000. The remaining € 50.000 will be paid out by the Alzheimer Research Foundation (SAO-FRA).

Besides that, also one Pilot Grant will be selected & funded by the “Fund A.B.”, managed by the King Baudouin Foundation for an amount of €50.000.

 

Lewy Body Grant Applications:

 

With the call of 2018 also a Standard Grant Application for Lewy Body research will be made available by the Fund Bonmariage de Bouyalski which is managed by the King Baudouin Foundation. Research proposals have to be written for a 2-years award period. The amount of this award is fixed at € 150.000. Only scientists, with a minimum of three years post PhD graduation date at the start of the Award period, are eligible applicants in this award category. Applicants should be experienced in research into Lewy Body disease.

Adjustments for career interruptions can be requested by the applicant in writing to the Chair of the Scientific Advisory Board (SAB) via scientific.secretariat@stopalzheimer.be. These would include, but are not limited to, family leave and major illness or injury. It is the responsibility of the applicant to point out and document such interruptions.

Multiple investigators of the same department, laboratory can apply in the same grant cycle year for a research award, pilot or standard, provided that there is no scientific or financial overlap between their grant application proposals.

 

STEP BY STEP GUIDELINES AND INSTRUCTIONS

Applications should be completed through the online Optimy platform taking into account the following guidelines and Instructions and meeting the Award Terms and Conditions.

STYLE AND FONT: It is obligatory to use Calibri, font 11, single spacing, to fill in the application form. Other styles or fonts are NOT accepted.

FRONT PAGE:

TITLE OF GRANT APPLICATION: Choose a title that is descriptive for the research outlined in the grant application. The text box allows for approximate 100 characters spaces included.

PRINCIPAL INVESTIGATOR: Name, Telephone Number and E-mail address of the Principle Investigator i.e. the person who will be responsible for executing the proposed Research Plan. List only one Principal Investigator.

A Principle Investigator can submit only one grant application per SAO-FRA grant application cycle. A new grant application cannot scientifically or financially overlap in time with a preceding awarded grant application. This implies that current awardees can submit at the earliest a new grant application in the last year of a preceding active 2-year award including awards of which the award period has been extended.

Investigators of the same laboratory can submit a Standard or Pilot grant application in the same grant application cycle provided that there is no scientific or financial overlap between the grant applications or with active awards of other investigators in their laboratory.

RESEARCH ORGANIZATION: Provide for the Principle Investigator the location where the research will be executed including Research Organization Name, Department, Laboratory and Postal Address. This address is where the Principle Investigator is working on a daily basis and is to be reached. The address of the Research Organization can be different from that of the Authorized Organization.

HEAD OF LABORATORY: Provide Name, Telephone Number and E-mail of the Head of the Laboratory in which the applicant will be performing the proposed research.

AUTHORIZED ORGANIZATION: Provide Name and Postal Address of the Authorized Organization that will be legally and financially responsible for the research and financial activities awarded by the SAO-FRA.

AUTHORIZED ORGANIZATION OFFICIAL: Enter Name, Position Title, Telephone

Number and E-mail Address of the Authorized Organization Official acting for the Principle Investigator and accepting the Award in agreement with the general obligations outlined in the SAO-FRA Award Terms and Conditions.

AUTHORIZED FINANCIAL OFFICIAL: Enter Name, Position Title, Telephone

Number and E-mail Address of the Authorized Financial Official acting for the Principle Investigator and taking the responsibility for the financial accounting in agreement with the financial obligations outlined in the SAO-FRA Award Terms and Conditions.

TYPE OF AUTHORIZED ORGANIZATION:

Indicate whether your Authorized Organization is a Public or Private non-profit organization. SAO-FRA provides awards only to non-profit organizations.

AUTHORIZED SIGNATURES PAGE: A “per” signature is not acceptable.

  1. Standard Grant Applications:

PRINCIPAL INVESTIGATOR: Insert name of Principle Investigator in the header.

With this original signature, the Principal Investigator signing the grant application confirms that he/she read the SAO-FRA Award Terms and Conditions of which he/she accepts scientific obligations on behalf of his/her organization, including the timely delivery of the yearly scientific progress reports.

However, when the principal investigator is not the head of the laboratory, an original signature of the head of the laboratory is required.

  1. Pilot Grant Applications:

PRINCIPAL INVESTIGATOR: Insert name of Principle Investigator in the header.

With this original signature, the Principal Investigator signing the grant application confirms that he/she read the SAO-FRA Award Terms and Conditions of which he/she accepts scientific obligations on behalf of his/her organization, including timely delivery of the yearly scientific progress reports.

However, when the principal investigator is not the head of the laboratory an original signature of the head of the laboratory is required.

INFORMATION DUTIES: In both cases, Standard Grant Applications or Pilot Grant Applications, it is the Principal Investigator’s duty to inform his/her head of laboratory and/or organization official about the application.

 

RESEARCH SUMMARY: State the hypothesis, general objective and specific aims of the proposed research. Describe, briefly and concisely, the experimental design and methods for achieving these goals. The summary is meant to serve as a succinct and accurate description of the Research Plan when separated from the grant application. The text box allows for approximate 3,000 characters spaces included.

RESEARCH RELEVANCE: State briefly and concisely, how the Research Plan will be relevant to Alzheimer disease and related disorders. The text box allows for approximate 1,000 characters spaces included.

KEY SCIENTIFIC PERSONNEL: only valid for Standard Grant Applications! Key personnel are scientific team members belonging to the Laboratory of the Principle Investigator submitting a standard grant application. This Laboratory should be identical to what is indicated on the front page under Research Organisation. Add Name, Position Title and Time in Research (%) of the Principal Investigator and Key Scientific Persons that will contribute to the execution of the proposed research.

Role of Key Scientific Personnel: Describe the specific role of the Principal Investigator and other Key Scientific Personnel. Only include scientific personnel e.g. PhD Student, Postdoctoral Scientist, Project Leader, Group Leader, etc.

BIOGRAPHICAL SKETCHES: Provide a maximal 4-page bio sketch of education, professional experiences, honors and awards, research funding and publications of the Principal Investigator. Start with the bio sketch of the Principle Investigator.

Standard Grant Applications: Add a biographical sketch for each Key Scientific Person.

Pilot Grant Applications: Add a bio sketch of the Head of the Laboratory in which the applicant will be performing the proposed research. The bio sketch should be restricted to the last 3 years.

RESEARCH PLAN: The Research Plan should include the following sections: General and Specific Aims of the proposed research, Background and Significance, Preliminary Data if applicable and Experimental Design and Methods.

Appendices: Submitting additional documents with the grant application such as manuscripts is not allowed. All research information that is essential to the international peer review evaluation of the grant application should be incorporated within the Research Plan.

General and Specific Aims: Provide a short state of the art, hypotheses, general objective and specific aims, and describe concisely and realistically what the research described in this application is intended to accomplish.

Background and Significance: Briefly summarize the background to the proposed research, critically evaluate existing knowledge, and specifically identify the gaps which the Research Plan intends to fill. State concisely the importance and relevance of the Research Plan to Alzheimer disease and related disorders.

Preliminary Data: Provide a concise summary of scientific data that has already been obtained by the Principal Investigator and/or Key Personnel in support of the general and specific aims stated in this grant application.

Experimental Design and Methods: Outline the experimental design and the procedures to be used to accomplish the specific aims of the Research Plan. Include the means by which the data will be collected, analyzed, and interpreted. Describe any new methodology and its advantage over existing methodologies. Discuss the potential difficulties and limitations of the proposed procedures and alternative approaches to achieve the aims.

Figures: Enter relevant figures (jpg, gif, png or tif format) cited in the Research Plan, and provide a figure title and legend.

Literature Cited: List references cited in the Research Plan. Each literature citation must include the names of up to a maximum of seven authors, the title, the name of the book or journal, year of publication, volume number and page numbers. Use the following reference manager style:

Sleegers K, Lambert JC, Bertram L, Cruts M, Amouyel P, Van Broeckhoven C. The pursuit of susceptibility genes for Alzheimer’s disease: progress and prospects. Trends Genet. 2010 26(2):84-93

ASSURANCES AND CERTIFICATIONS: SAO-FRA will only award grant applications that fulfill the ethical and legal requirements for research using human subjects and/or vertebrate animals in a research environment that protects both the safety of the researchers and the environment.

HUMAN SUBJECTS/VERTEBRATE ANIMALS: If research activities involving human subjects or vertebrate animals are planned at any time in the Research Plan, indicate “Yes” and briefly explain. If your grant application is awarded, a signed approval by the appropriate ethical committee(s) of the Principal Investigator’s organization of the Research Plan described in the grant application will be requested and must be provided before funds are released. The ethical approval(s) should be written in English and state the name of the Principle Investigator, the title of the grant application, the SAO-FRA Award Number, and the Award Period.

BIOSAFETY AND BIOTECHNOLOGY: Indicate whether the Research Plan involves the use and/or production of hazardous biomaterials, recombinant DNA or genetically engineered organisms. If yes, briefly explain. Provide for your research organization the legal authorization and provide permission number and period.

Important notice: If any delay occurs in obtaining the necessary certificates, the principal investigator must inform the scientific secretariat of SAO-FRA and confirm that he/she will deliver the necessary certificates as soon as possible.

BUDGET TABLE & JUSTIFICATION: For a 2-year SAO-FRA Standard Grant application the budget is € 150.000 and € 75.000 for a Pilot Grant application.

SAO-FRA does not fund the salary of the Principal Investigator except for Pilot Grant applications. Indicate the total salary cost per year. SAO-FRA will not fund the purchase of large capital equipment. Maximum yearly budget in the equipment category is € 3.000. Travel must be relevant to the accomplishment of the Research Plan. Maximum cost in this category is € 2.000. First class travel may not be used. The budget cannot contain any administrative overhead or any other peripheral costs.

A transfer of less than € 10.000 between budget categories does not require justification and prior approval by the SAO-FRA. Transfer of more than € 10.000 from one budget category to another does require justification and prior approval by the scientific advisory board of SAO-FRA.

Budget Justification: Provide a brief justification and rationale for each of the budget categories i.e. personnel, supplies, equipment and travel.

Personnel: Include the name of the person(s) to be paid if the grant application is approved for funding. Also, include for these persons the Name, Position Title and Time in Research (%) under Key Personnel.

Supplies: Itemize supplies in separate categories. If vertebrate animals are to be involved, state how many are to be used, their unit purchase price and their unit care cost.

Equipment: List each item and describe briefly.

Travel: State the purpose of the travel.

RESEARCH ENVIRONMENT: Provide information on the research environment in which the proposed research will be executed e.g. expertise (centralized and core) facilities, major equipment, relevant scientific resources.

AVAILABLE OTHER SUPPORT: List all current and pending financial support related to the proposed research with name of funding agency, type of grant (e.g. research project, fellowship, travel grant, mobility grant, etc.), title, funding period, total amount in €.

SAO-FRA does not allow its funds to be used for research funded by another funding agency without its full knowledge. Failure to report the receipt of overlapping funds may require, as determined at the sole discretion of SAO-FRA, the return of all funds awarded by SAO-FRA.

RESEARCH AREAS: Provide maximum two keywords that describe the general research area and maximum three keywords that describe the specific research area(s) expertise needed to adequately review your grant application.

INTERNATIONAL REVIEWERS: You are allowed to exclude a maximum of 3 International Reviewers from reviewing your grant application.

INSTRUCTIONS FOR SUBMISSION: Grant applications must be submitted in time on the Optimy platform.

Incomplete grant applications that don’t comply with the SAO-FRA Application Guidelines and Instructions and the SAO-FRA Award Terms and Conditions, or submitted after the application deadline will NOT enter the review process.

 

For information and questions contact the SAO-FRA Scientific Secretariat:

SAO-FRA Scientific Secretariat

Contact: Kim Plasman

Tel: +32 56 922 899  (on Monday, Wednesday afternoon and Friday).

E-mail scientific.secretariat@stopalzheimer.be

 

 

Scientific Advisory Board of SAO-FRA

Chair : Prof. Peter-Paul De Deyn (UA)

Campus Drie Eiken

Universiteitsplein 1 D.T. 698

2610 Wilrijk

Tel : 03/265.26.20

E-mail : peter.dedeyn@uantwerpen.be